The current study is a conceptual replication of Wang using a pretest-posttest design and an online sample through Amazon’s Mechanical Turk. Seventy-one Asian-Americans recalled a recent memory before and after being primed as either Asian or American. On pre-prime memories, conditions did not significantly differ. However, on post-prime memories, participants primed as American recalled more self-focused memories than relationally focused memories and those primed as Asian recalled more relationally focused memories than self-focused memories. In addition, memories of Asian-Americans primed as (...) American consisted of a smaller proportion of social interaction instances than those primed as Asian. In total, 6 of the 8 effects found in Wang were replicated. We discuss the implications that the current results and past studies have on our understanding of how culture influences memory encoding and retrieval. (shrink)

The current research examined whether fair consideration—a social norm that people inherently prefer to confirm—would modulate face recognition. Each neutral face was associated with fair offers or unfair offers via an economic decision task, the Ultimatum Game (UG) task. After the UG, participants were asked to identify the faces of proposers who made different offers. Enhanced memory was observed for fair-related faces compared to unfair-related faces. Furthermore, high trait anxiety was associated with reduced memory for fair-related faces. These results were (...) further confirmed by signal detection theory. The current research provided initial evidence that people showed enhanced memory for faces that made fair offers from the economic decision task, and that high trait anxiety was associated with reduced fair-related memory. Possible neural mechanisms and the implication in economic and social situations have been discussed. (shrink)

The current research investigated the role of gratitude in economic decisions about offers that vary in fairness yet benefit both parties if accepted. Participants completed a trait/dispositional gratitude measure and then were randomly assigned to recall either an event that made them feel grateful or the events of a typical day. After the gratitude induction task, participants played the ultimatum game, deciding whether to accept or reject fair offers and unfair offers from different proposers. Results showed that trait gratitude was (...) positively correlated with respondents’ acceptance of unfair offers. However, experimentally induced momentary gratitude did not influence acceptance of unfair offers. The trait or disposition to be grateful involves the enduring capacity across different types of situations and benefactors to see the good that is present, even when that benefit is small. Accordingly, dispositional gratitude – but not momentarily induced gratitude – was associated with a greater propensity to accept even the small benefits within unfair offers which otherwise pose barriers to making the effective economic decision of accepting offers regardless of their relative size. (shrink)

"The mind once enlightened cannot again become dark." As an English corset-maker's son, Thomas Paine was expected to spend his life sewing women's underwear. But as a teenager, Thomas dared to change his destiny, enduring years of struggle until a meeting with Benjamin Franklin brought Thomas to America in 1774-and into the American Revolution. Within fourteen months, Thomas would unleash the persuasive power of the written word in Common Sense-a brash wake-up call that rallied the American people to declare (...) independence against the mightiest empire in the world. This fascinating and extensively researched biography, based on numerous primary sources, will immerse readers in Thomas Paine's inspiring journey of courage, failure, and resilience that led a penniless immigrant to change the world with his words. (shrink)

Problem one: why, if God designed the human mind, did it take so long for humans to develop theistic concepts and beliefs? Problem two: why would God use evolution to design the living world when the discovery of evolution would predictably contribute to so much nonbelief in God? Darwin was aware of such questions but failed to see their evidential significance for theism. This paper explores this significance. Problem one introduces something I call natural nonbelief, which is significant because it (...) parallels and corroborates well-known worries about natural evil. Problems one and two, especially when combined, support naturalism over theism, intensify the problem of divine hiddenness, challenge Alvin Plantinga’s views about the naturalness of theism, and advance the discussion about whether the conflict between science and religion is genuine or superficial. (shrink)

Some philosophers have argued for what I call the reason-giving requirement for conscientious refusal in reproductive healthcare. According to this requirement, healthcare practitioners who conscientiously object to administering standard forms of treatment must have arguments to back up their conscience, arguments that are purely public in character. I argue that such a requirement, though attractive in some ways, faces an overlooked epistemic problem: it is either too easy or too difficult to satisfy in standard cases. I close by briefly considering (...) whether a version of the reason-giving requirement can be salvaged despite this important difficulty. (shrink)

According to the Bayesian paradigm in the psychology of reasoning, the norms by which everyday human cognition is best evaluated are probabilistic rather than logical in character. Recently, the Bayesian paradigm has been applied to the domain of argumentation, where the fundamental norms are traditionally assumed to be logical. Here, we present a major generalisation of extant Bayesian approaches to argumentation that utilizes a new class of Bayesian learning methods that are better suited to modelling dynamic and conditional inferences than (...) standard Bayesian conditionalization, is able to characterise the special value of logically valid argument schemes in uncertain reasoning contexts, greatly extends the range of inferences and argumentative phenomena that can be adequately described in a Bayesian framework, and undermines some influential theoretical motivations for dual function models of human cognition. We conclude that the probabilistic norms given by the Bayesian approach to rationality are not necessarily at odds with the norms given by classical logic. Rather, the Bayesian theory of argumentation can be seen as justifying and enriching the argumentative norms of classical logic. (shrink)

In his article entitled 'Divine hiddenness and the demographics of theism' ("Religious Studies", 42 (2006), 177–191), Stephen Maitzen draws our attention to an important feature that is often overlooked in discussion about the argument from divine hiddenness (ADH). His claim is that an uneven distribution of theistic belief (and not just the mere existence of non-belief) provides an atheological challenge that cannot likely be overcome. After describing what I take to be the most pressing feature of the problem, I argue (...) that a hidden premise causes Maitzen to overlook a Molinist solution. The upshot is a softening of the atheological import of the demographic data. (shrink)

v. 1. Charmides. Lysis. Laches. Protagoras. Euthydemus. Cratylus. Phaedrus. Ion. Symposium.--v. 2. Meno. Euthyphro. Apology. Crito. Phaedo. Georgias. Appendix I: Lesser Hippias. Alcibiades I. Menexenus. Appenddix II: Alcibiades II. Eryxias.--v. 3. Republic. Timaeus. Critias.--v. 4. Pharmenides. Theaetetus. Sophist. Statesman. Philebus.--v. 5 Laws. Index to the writings of Plato.

Empathy is a construct that is notoriously difficult to define. Murphy and colleagues argue for leaning into the construct's inherent fuzziness and reverting to what they term a classical definition informed by the observations of philosophers and clinicians: as a dynamic, “unfolding process of imaginatively experiencing the subjective consciousness of another person, sensing, understanding, and structuring the world as if one were that person.” Although consistent with some historical conceptualizations, this definition risks incorporating so many processes it would make empathy (...) difficult to operationalize or distinguish from any generally socially sensitive interaction. Defining empathy instead as the attempted representation, or simulation, of another's subjective internal experiences would increase its clarity and empirical utility. (shrink)

Empathy is a construct that is notoriously difficult to define. Murphy and colleagues argue for leaning into the construct's inherent fuzziness and reverting to what they term a classical definition informed by the observations of philosophers and clinicians: as a dynamic, “unfolding process of imaginatively experiencing the subjective consciousness of another person, sensing, understanding, and structuring the world as if one were that person.” Although consistent with some historical conceptualizations, this definition risks incorporating so many processes it would make empathy (...) difficult to operationalize or distinguish from any generally socially sensitive interaction. Defining empathy instead as the attempted representation, or simulation, of another's subjective internal experiences would increase its clarity and empirical utility. (shrink)

Philosophy & Public Affairs, Volume 50, Issue 2, Page 239-266, Spring 2022.

Loneliness in medicine is a serious problem not just for patients, for whom illness is intrinsically isolating, but also for physicians in the contemporary condition of medicine. We explore this problem by investigating the ideal physician-patient relationship, whose analogy with friendship has held enduring normative appeal. Drawing from Talbot Brewer and Nir Ben-Moshe, we argue that this appeal lies in a dynamic form of companionship incompatible with static models of friendship-like physician-patient relationships: a mutual refinement of embodied virtue that draws (...) both persons together. The ideal physician-patient relationship has a dialectical character that fosters each member's improvement of phenomenologically recognizing and embodying moral virtues. A key component of this dynamic is a commitment to the common goal of the patient's health, realized through joint interactivities and conversations over time. The physician's presence to the patient's suffering—understood best as an alienating phenomenological condition for the patient—orients and discloses possibilities for virtuous caregiving by structuring the meanings of the goals, conversations, and joint narrative constitutive of their relationship. Presence to suffering, paradoxically, is perhaps an important prerequisite for this dynamic partnership. These activities dialectically build an interpretive horizon of understanding through which moral goods and character refinement—in and for the other—may become revealed for both persons in their shared being-in-the-world. This analysis of suffering, mood, and revealing of (possible) moral goods has implications for addressing the modern problem of loneliness for patients and physicians, who are increasingly inhibited from building flourishing relationships with each other. (shrink)

It has been shown that for the Reissner-Nordström solution to the vacuum Einstein field equations charge, like mass, has a unique space-time signature (Marsh, Found. Phys. 38:293–300, 2008). The presence of charge results in a negative curvature. This work, which includes a discussion of effective mass, is extended here to the Kerr-Newman solution.

In lieu of an abstract, here is a brief excerpt of the content:Flipping the DeckOn Totality and Infinity’s Transcendental/Empirical PuzzleJack Marsh (bio)How does one perceive a transcendental condition?— Martin Kavka... if it is legitimate to hold Levinas to the standards that he himself imposes on certain other philosophers.— Robert BernasconiI do not believe that there is a transparency possible in method. Nor that philosophy might be possible as transparency.— Emmanuel LevinasThe question of the precise methodological status of the face (...) has yet to be satisfactorily resolved. The best evidence for this claim perhaps lies in texts intended to introduce Levinas to a general philosophical audience. If even first-rate philosophers wrestle still with the puzzle Totality and Infinity bequeaths us, we seem to still await a full and precise diagnosis. For example, Michael Morgan holds the “face-to-face and the responsible self — they are one thing characterized from [End Page 79] two perspectives — are” “the transcendental condition for meaningful human life,” yet elsewhere concedes, “it is unavoidable that in some sense or other the face-to-face does occur as an actually lived experience.” If Morgan’s own nuanced treatment of this question still lands him in equivocation, the problem is certainly not Morgan’s own.1 As Atterton notes, Morgan must finally hold that Levinas’s method is a “transcendental enterprise of a certain sort.”2 But of what sort? Indeed, this question has been asked or analyzed in one way or another from the beginning of Totality and Infinity’s English-language reception.3 Of course, Derrida was the first to broach the question of Totality and Infinity’s general intelligibility, alleging that Levinas ultimately succumbs to a form of empiricism. Of course, de Boer was the first to mount a rigorous Cartesian reading of the text as an (apparently) “ethical transcendental philosophy.” Of course, Bernasconi’s response to de Boer, and his creative repetition of Derrida’s critical point, was the first to give the problem a precise formulation.4 Derrida, de Boer, and Bernasconi hand us the now canonical problem of what I will call the text’s “transcendental/empirico-metaphysical puzzle.”5 The issue boils down to Levinas’s dual insistence that the face “cannot... be stated in terms of experience,” yet is nevertheless “reflected within experience” (TI 25, 23, 67, 260). How should we understand Levinas’s references to various “formal structure[s]” — “of language,” “of interpellation,” “of the idea of infinity” — next to talk of “pure” or “concrete moral experience” (195, 79, 64, 53)? Does the Other occur in “pure experience,” or is she “deduced” as a condition of possibility for experience in general? In this essay, I will propose an internal explanation for Totality and Infinity’s longstanding methodological puzzle. By proposing to “explain” this puzzle, I am making at least three distinct claims: to show (1) that the text suffers from genuine incoherence, thus confirming the general criticism of Derrida, Bernasconi, and others, (2) precisely how this incoherence follows from the details of Levinas’s own explicit method, and (3) precisely why, philosophically, he may have constructed and performed his method as he did.6 By proposing to explain the book’s incoherence, I can [End Page 80] also make specific hermeneutic predictions. If Totality and Infinity’s transcendental/empirico-metaphysical puzzle is genuinely aporetic, it follows that no resolution to it is possible on the text’s own terms.7 As such, any attempt to resolve the puzzle must either (1) augment the text’s own descriptions, (2) utilize other philosophical resources to render its claims coherent, or (3) precisely attempt resolution in either a transcendental or empirico-metaphysical direction. As it turns out, extant scholarship reflects just these hermeneutic strategies.Over the years many philosophers have contributed to this longstanding debate, variously arguing for or against the general intelligibility of Levinas’s account of the face. On the one hand, scholarship that questions the text’s intelligibility does so from a variety of methodological perspectives.8 On the other hand, scholarship that mounts a defense of the text seems to proceed in one of three ways: by (1) apparently repeating Totality and Infinity’s methodological problems, (2) anticipating Levinas’s later work, read... (shrink)

The purpose of this paper is to provide a justification of punishment which can be endorsed by free will skeptics, and which can also be defended against the "using persons as mere means" objection. Free will skeptics must reject retributivism, that is, the view that punishment is just because criminals deserve to suffer based on their actions. Retributivists often claim that theirs is the only justification on which punishment is constrained by desert, and suppose that non-retributive justifications must therefore endorse (...) treating the people punished as mere means to social ends. Retributivists typically presuppose a monolithic conception of desert: they assume that action-based desert is the only kind of desert. But there are also personhood-based desert claims, that is, desert claims which depend not on facts about our actions, but instead on the more abstract fact that we are persons. Since personhood-based desert claims do not depend on facts about our actions, they do not depend on moral responsibility, so free will skeptics can appeal to them just as well as retributivists. What people deserve based on the mere fact of their personhood is to be treated as they would rationally consent to be treated if all they had in view was the mere fact of their personhood. We can work out the implications of this view for punishment by developing a hypothetical consent justification in which we select principles of punishment in the Rawlsian original position, so long as we are careful not to smuggle in the retributivist assumption that it is under our control whether we end up as criminals or as law-abiding citizens once we raise the veil of ignorance. (shrink)

In this article, we address a major outstanding question of probabilistic Bayesian epistemology: how should a rational Bayesian agent update their beliefs upon learning an indicative conditional? A number of authors have recently contended that this question is fundamentally underdetermined by Bayesian norms, and hence that there is no single update procedure that rational agents are obliged to follow upon learning an indicative conditional. Here we resist this trend and argue that a core set of widely accepted Bayesian norms is (...) sufficient to identify a normatively privileged updating procedure for this kind of learning. Along the way, we justify a privileged formalization of the notion of ‘epistemic conservativity’, offer a new analysis of the Judy Benjamin problem, and emphasize the distinction between interpreting the content of new evidence and updating one’s beliefs on the basis of that content. (shrink)

It is a consequence of the theory of imprecise credences that there exist situations in which rational agents inevitably become less opinionated toward some propositions as they gather more evidence. The fact that an agent's imprecise credal state can dilate in this way is often treated as a strike against the imprecise approach to inductive inference. Here, we show that dilation is not a mere artifact of this approach by demonstrating that opinion loss is countenanced as rational by a substantially (...) broader class of normative theories than has been previously recognised. Specifically, we show that dilation-like phenomena arise even when one abandons the basic assumption that agents have (precise or imprecise) credences of any kind, and follows directly from bedrock norms for rational comparative confidence judgements of the form `I am at least as confident in p as I am in q'. We then use the comparative confidence framework to develop a novel understanding of what exactly gives rise to dilation-like phenomena. By considering opinion loss in this more general setting, we are able to provide a novel assessment of the prospects for an account of inductive inference that is not saddled with the inevitability of rational opinion loss. (shrink)

I defend a deontological social contract justification of punishment for free will deniers. Even if nobody has free will, a criminal justice system is fair to the people it targets if we would consent to it in a version of original position deliberation (OPD) where we assumed that we would be targeted by the justice system when the veil is raised. Even if we assumed we would be convicted of a crime, we would consent to the imprisonment of violent criminals (...) if prison conditions were better than the state of nature but deterring enough to prevent the state of nature. And even if we assumed we would be accused of a crime, we would consent to an evidentiary standard low enough to allow a conviction rate sufficient to prevent the state of nature. After explaining this justification, I contrast it with the public health quarantine justification defended by Derk Pereboom and Gregg Caruso, and argue that it provides a stronger response to the using criminals as mere means objection. (shrink)

Stasis is a process of classical rhetoric that identifies the core issue in a trial or a similar debate. Hermagoras of Temnos included the first comprehensive analysis of stasis in his second-century BCE treatise on rhetoric, now lost. Modern scholars tend to echo George Kennedy, who maintains that Hermagoras’ inspiration for the hierarchical structure of stasis is indeterminate. This article, however, employs scholarship in legal semiotics, including the work of Miklós Könczöl and Bernard S. Jackson, to argue that Hermagoras based (...) stasiastic structure on Aristotle’s first-figure syllogism. Ideally, knowledge of that structure can enhance modern applications of stasis. (shrink)

Schupbach and Sprenger introduce a novel probabilistic approach to measuring the explanatory power that a given explanans exerts over a corresponding explanandum. Though we are sympathetic to their general approach, we argue that it does not adequately capture the way in which the causal explanatory power that c exerts on e varies with background knowledge. We then amend their approach so that it does capture this variance. Though our account of explanatory power is less ambitious than Schupbach and Sprenger’s in (...) the sense that it is limited to causal explanatory power, it is also more ambitious because we do not limit its domain to cases where c genuinely explains e. Instead, we claim that c causally explains e if and only if our account says that c explains e with some positive amount of causal explanatory power. 1Introduction 2The Logic of Explanatory Power 3Subjective and Nomic Distributions 3.1Actual degrees of belief 3.2The causal distribution 4Background Knowledge 4.1Conditionalization and colliders 4.2A helpful intervention 5Causal Explanatory Power 5.1The applicability of explanatory power 5.2Statistical relevance ≠ causal explanatory power 5.3Interventionist explanatory power 5.4E illustrated 6Conclusion. (shrink)

When viewing a circular coin rotated in depth, it fills an elliptical region of the distal scene. For some, this appears to generate a two-fold experience, in which one sees the coin as simultaneously circular (in light of its 3D shape) and elliptical (in light of its 2D ‘perspectival shape’ or ‘p-shape’). An energetic philosophical debate asks whether the latter p-shapes are genuinely presented in perceptual experience (as ‘perspectivalists’ argue) or if, instead, this appearance is somehow derived or inferred from (...) experience (as ‘anti-perspectivalists’ argue). This debate, however, has largely turned on introspection. In a recent study, Morales, Bax, and Firestone (2020) aim to provide the first empirical test of this question. They asked subjects to find an elliptical coin seen face-on from a search array that also included a circular coin seen either face-on or at an angle. They found that subjects reacted more slowly when the distracting circle was seen at an angle, such that it’s p-shape matched that of the target ellipse. From this, they concluded that the similar p-shape between the ellipse and circle constituted a phenomenal similarity between the two, and thus that perspectivalism is true. We show that these results can also be explained by pre-attentive guidance by unconscious representations (in what follows, just “unconscious pre-attentive guidance”) and that this explanation is at least as plausible as one from phenomenal similarity. Thus, we conclude that the experiment does not support perspectivalism over anti-perspectivalism. (shrink)

An apparently increasing number of philosophers take free will skepticism to pose a serious challenge to some of our practices. This must seem odd to many—why should anyone think that free will skepticism is relevant for our practices, when nobody seems to think that other canonical forms of philosophical skepticism are relevant for our practices? Part of the explanation may be epistemic, but here I focus on a metaethical explanation. Free will skepticism is special because it is compatible with ‘basic (...) moral reasons’—moral reasons acknowledged by all mainstream ethicists—and other minds and induction skepticism are not. One example is our reason not to intentionally harm others. Practical seriousness about other minds and induction skepticism undermines this reason, but practical seriousness about free will skepticism only undermines a potential overrider of this reason, that is, the reason of retribution. (shrink)

This text is a translation of an article of B.L. Whorf “Language, mind and reality" (first published in 1941). The text was originally written for the journal Theosophist (India) during the last year of Whorf's life. The article contains a formulation of the principle of linguistic relativity that relates to the idea of that the world picture of a user of a language depends on the grammar of the language she is using. The article also contains a critique of the (...) Western science from Whorf's theosophist perspective. The paper was translated in Russian by Andrey A. Veretennikov. (shrink)

This paper argues that Kant endorses a distinction between rational and natural sympathy, and it presents an interpretation of rational sympathy as a power of voluntarya posterioriproductive imagination. In rational sympathy we draw on the imagination’s voluntary powers (a) to subjectively unify the contents of intuition, in order to imaginatively put ourselves in others’ places, and (b) to associate imagined intuitional contents with the concepts others use to convey their feelings, in such a way that those contents prompt feelings in (...) us that are like their feelings. (shrink)

Featuring a new, explanatory Foreword by Justice Cardozo's premier biographer, this renowned and much-used analysis of the process of judicial decision-making includes embedded page numbers from the original 1921 edition for continuity of citations and syllabi.

Volume 20, Issue 4, May 2020, Page 102-103.

We investigate the interactions between scalar implicatures and presuppositions in sentences containing both a scalar item and presupposition trigger. We first critically discuss Gajewski and Sharvit’s previous approach. We then closely examine two ways of integrating an exhaustivity-based theory of scalar implicatures with a trivalent approach to presuppositions. The empirical side of our discussion focuses on two novel observations: the interactions between prosody and monotonicity, and what we call presupposed ignorance. In order to account for these observations, our final proposal (...) relies on two mechanisms of scalar strengthening, the Presupposed Ignorance Principle and an exhaustivity operator which lets the presuppositions of negated alternatives project. (shrink)

The goal of this paper is to explain and defend the following argument: (1) If it can be reasonably doubted that someone had free will with respect to some action, then it is a requirement of justice to refrain from doing serious retributive harm to him in response to that action. (2) Anyone who believes the free will debate to be philosophically valuable must accept that it can be reasonably doubted that anyone ever has free will. (3) Therefore, anyone who (...) believes the free will debate to be philosophically valuable must accept that it is a requirement of justice to refrain from serious retributive harm. (shrink)

In the fifth century BCE, Melissus of Samos developed wildly counterintuitive claims against plurality, change, and the reliability of the senses. This book provides a reconstruction of the preserved textual evidence for his philosophy, along with an interpretation of the form and content of each of his arguments. A close examination of his thought reveals an extraordinary clarity and unity in his method and gives us a unique perspective on how philosophy developed in the fifth century, and how Melissus came (...) to be the most prominent representative of what we now call Eleaticism, the monistic philosophy inaugurated by Parmenides. The rich intellectual climate of Ionian enquiry in which Melissus worked is explored and brought to bear on central questions of the interpretation of his fragments. This volume will appeal to students and scholars of early Greek philosophy, and also those working on historical and medical texts. (shrink)

In an original and provocative study of suicide, Ian Marsh examines the historical and cultural forces that have influenced contemporary thought, practices and policy in relation to this serious public health problem. Drawing on the work of French philosopher Michel Foucault, the book tells the story of how suicide has come to be seen as first and foremost a matter of psychiatric concern. Marsh sets out to challenge the assumptions and certainties embedded in our beliefs, attitudes and practices (...) concerning suicide and the suicidal, and the resulting account unsettles and informs in equal measure. The book will be of particular interest to researchers, professionals and students in psychology, history, sociology and the health sciences. (shrink)

Schupbach and Sprenger introduce a novel probabilistic approach to measuring the explanatory power that a given explanans exerts over a corresponding explanandum. Though we are sympathetic to their general approach, we argue that it does not adequately capture the way in which the causal explanatory power that c exerts on e varies with background knowledge. We then amend their approach so that it does capture this variance. Though our account of explanatory power is less ambitious than Schupbach and Sprenger’s in (...) the sense that it is limited to causal explanatory power, it is also more ambitious because we do not limit its domain to cases where c genuinely explains e. Instead, we claim that c causally explains e if and only if our account says that c explains e with some positive amount of causal explanatory power. (shrink)

Modern converged mass media, particularly television and the World Wide Web, may be fostering a new orality in opposition to traditional alphabetical literacy. Scholars of orality and literacy maintain that oral cultures feature reduced levels of critical assessment of media messages. An analysis of Aristotle's description of ethos, as presented in that philosopher's Rhetoric, suggests that an oral culture can foster media that deliver selective truths, or even lies, thus ranking poorly in hierarchical ethical schemata such as those developed by (...) Kohlberg, Gilligan, and Baker. (shrink)

Free radicals are generally perceived as highly reactive species which are harmful to biological systems. There are, however, a number of enzymes that use carbon‐based radicals to catalyse a variety of important and unusual reactions. The most prominent example is ribonucleotide reductase, an enzyme which is crucial for the synthesis of DNA. In general, radicals are used to remove hydrogen from unreactive positions in the substrate, and in this way the substrate is activated to undergo chemical transformations that would otherwise (...) be difficult to achieve. Several different mechanisms have evolved which allow enzymes to generate and maintain radicals in increasingly aerobic enviroments. An unexpected finding is the existance of stable protein‐based radicals, residing on a variety of amino‐acid side chains, which serve to link the radical‐generating and catalytic sites and to store the radical between turnovers. (shrink)

Neurodegenerative diseases are becoming increasingly common as life expectancy increases. Recent years have seen tremendous progress in the identification of genes that cause these diseases. While mutations have been found and cellular processes defined that are altered in the disease state, the identification of treatments and cures has proven more elusive. The process of finding drugs and therapies to treat human diseases can be slow, expensive and frustrating. Can model organisms such as Drosophila speed the process of finding cures and (...) treatments for human neurodegenerative diseases? We pose three questions, (1) can one mimic the essential features of human diseases in an organism like Drosophila, (2) can one cure a model organisms of human disease and (3) will these efforts accelerate the identification of useful therapies for testing in mice and ultimately humans? Here we focus on the use of Drosophila to identify potential treatments for neurodegenerative diseases such as Huntington's and we discuss how well these therapies translate into mammalian systems. BioEssays 26:485–496, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Charge, like mass in Newtonian mechanics, is an irreducible element of electromagnetic theory that must be introduced ab initio. Its origin is not properly a part of the theory. Fields are then defined in terms of forces on either masses—in the case of Newtonian mechanics, or charges in the case of electromagnetism. General Relativity changed our way of thinking about the gravitational field by replacing the concept of a force field with the curvature of space-time. Mass, however, remained an irreducible (...) element. It is shown here that the Reissner-Nordström solution to the Einstein field equations tells us that charge, like mass, has a unique space-time signature. (shrink)